Salina lies at the mouth of Wied il-Għasel, a floodplain dominated by agriculture. The area has been under human influence since antiquity, with evidence of a Roman port and catacombs nearby.
In the 16th century, the Order of St. John built salt pans on the shallow estuary and for centuries, they were the main source of salt for the island. Production waned in the late 18th century, and eventually ceased altogether. The site became inactive for several decades and rare saltmarsh habitat re-established itself in some areas.
In 2008, restoration work began at Salina and in 2018, the site passed under BirdLife management to develop as a park and nature reserve.